Description

2-(3-Fluoro-2-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1417301-67-7 is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound serves as a critical intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), especially those containing fluorinated and methoxylated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic systems.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is crucial.
• Cross-Coupling Reactions: A dedicated reagent for palladium-catalyzed Suzuki-Miyaura couplings, facilitating carbon-carbon bond formation under mild conditions.
• Chemical Biology & Medicinal Chemistry: Utilized in library synthesis for drug discovery programs targeting a wide range of diseases.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts.

Basic Information

Product Name	2-(3-Fluoro-2-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1417301-67-7
Molecular Formula	C13H18BFO3
Molecular Weight	252.09 g/mol
Synonyms	(3-Fluoro-2-methoxyphenyl)boronic acid pinacol ester; 2-(3-Fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluoro-2-methoxybenzeneboronic acid pinacol ester; Pinacol (3-Fluoro-2-methoxyphenyl)boronate; (3-Fluoro-2-methoxyphenyl)BPin; 2-Methoxy-6-fluorophenylboronic acid pinacol ester; CAS 1417301-67-7
EINECS	Contact for details

Quality Control

Our production of 2-(3-Fluoro-2-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis including HPLC, NMR (1H, 13C, 19F, 11B), and GC to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.