Description

2-(3-Fluoro-2-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1417301-66-6 is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, active ingredient synthesis, and functional material development.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing biaryl and heterobiaryl scaffolds prevalent in modern drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures for enhanced activity and stability.
• Material Science Research: Serves as a precursor for creating organic electronic materials, including polymers and small molecules for OLEDs, OFETs, and other optoelectronic devices.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Chemical Biology & Diagnostics: Utilized in the synthesis of probes and tags for bio-conjugation and imaging applications, leveraging the boronate group's reactivity.
• Academic & Industrial R&D: A staple in laboratory-scale research for method development and exploring new synthetic pathways in organic chemistry.

Basic Information

Item	Details
Product Name	2-(3-Fluoro-2-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1417301-66-6
Molecular Formula	C₁₃H₁₈BFO₂
Molecular Weight	236.09 g/mol
Synonyms	3-Fluoro-2-methylbenzeneboronic acid pinacol ester; (3-Fluoro-2-methylphenyl)boronic acid pinacol ester; 2-Methyl-3-fluorophenylboronic acid pinacol ester; Pinacol (3-fluoro-2-methylphenyl)boronate; 3-Fluoro-2-methylphenyl-Bpin; 1417301-66-6; 2-(3-Fluoro-o-tolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Fluoro-2-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane undergoes rigorous analytical testing to ensure it meets the high standards required for sensitive cross-coupling applications. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC/NMR), assay, and impurity profiles is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent decomposition and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.