Description

2-[2-(Difluoromethoxy)-5-Fluorophenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and versatile building block in modern organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex fluorinated structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of biaryl systems.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates in oncology, CNS, and antiviral research.
• Suzuki-Miyaura Cross-Coupling: Essential boron reagent for palladium-catalyzed C-C bond formation to create complex biaryl structures.
• Agrochemical Research: Used in the development of new-generation fluorinated pesticides and herbicides.
• Material Science: Precursor for organic electronic materials, including OLEDs and semiconductors, where fluorination enhances stability and performance.
• Chemical Synthesis: Versatile reagent for introducing the 2-(difluoromethoxy)-5-fluorophenyl moiety into target molecules.
• Process Chemistry: Scalable intermediate for optimizing manufacturing routes for fluorinated APIs.

Basic Information

Product Name	2-[2-(Difluoromethoxy)-5-Fluorophenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1417301-27-9
Molecular Formula	C₁₃H₁₆BF₃O₃
Molecular Weight	288.07 g/mol
Synonyms	5-Fluoro-2-(difluoromethoxy)phenylboronic acid pinacol ester; (5-Fluoro-2-(difluoromethoxy)phenyl)boronic acid pinacol ester; 2-(Difluoromethoxy)-5-fluorophenylboronic acid pinacol ester; Pinacol [2-(difluoromethoxy)-5-fluorophenyl]boronate; [2-(Difluoromethoxy)-5-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 1417301-27-9; Boronic ester derivative of 5-fluoro-2-(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our production of 2-[2-(Difluoromethoxy)-5-Fluorophenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality protocols suitable for cGMP and pharmaceutical intermediate applications. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity and impurity profiles. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.