Description

3-(5-Hydroxy-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione is a high-purity pharmaceutical intermediate and building block of significant interest in modern drug discovery. This compound matters for its role as a key synthon in the development of novel therapeutic agents, particularly those targeting specific protein degradation pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of complex small-molecule drugs and PROTACs (Proteolysis Targeting Chimeras).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs).
• PROTAC Development: Serves as a key component in the linker or ligand design for Proteolysis Targeting Chimeras.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Chemical Biology Probes: Employed in the creation of molecular probes to study protein function and cellular pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds.

Basic Information

Product Name	3-(5-Hydroxy-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione
CAS No.	1416990-08-3
Molecular Formula	C13H12N2O4
Molecular Weight	260.25 g/mol
Synonyms	2,6-Dioxopiperidin-3-yl 5-hydroxy-2,3-dihydro-1H-isoindole-1-carboxylate; 3-(5-Hydroxy-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione; 5-Hydroxy-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Lenalidomide Impurity; Lenalidomide Related Compound; Thalidomide analogue intermediate; PROTAC linker precursor.
EINECS	Contact for details

Quality Control

Our 3-(5-Hydroxy-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.