Description

2-Bromo-3-Fluoropyridine-6-Carbonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitrile substituents on the pyridine ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine and bromine atoms enhance biological activity and metabolic stability.
• Material Science Research: Acts as a building block for creating functionalized ligands, organic semiconductors, and advanced polymers.
• Cross-Coupling Reactions: The bromine substituent is an excellent site for palladium-catalyzed reactions (e.g., Suzuki, Stille, Buchwald-Hartwig), enabling rapid diversification of the molecular core.
• Nitrile Functionalization: The cyano group can be transformed into various other functional groups, such as carboxylic acids, amides, or tetrazoles, expanding its utility in medicinal chemistry.

Basic Information

Product Name	2-Bromo-3-Fluoropyridine-6-Carbonitrile
CAS No.	1416713-45-5
Molecular Formula	C6H2BrFN2
Molecular Weight	200.99 g/mol
Synonyms	6-Bromo-5-fluoropyridine-2-carbonitrile; 5-Fluoro-6-bromopicolinonitrile; 2-Bromo-3-fluoropyridine-6-carbonitrile; 3-Fluoro-2-bromopyridine-6-carbonitrile; 2-Cyano-3-fluoro-6-bromopyridine; 6-Bromo-5-fluoro-2-cyanopyridine; 5-Fluoro-6-bromo-2-pyridinecarbonitrile; 1416713-45-5
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Fluoropyridine-6-Carbonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/GC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.