Description

Triflupromazine Hydrochloride-D6 is a deuterated internal standard of the phenothiazine antipsychotic triflupromazine, specifically designed for high-precision analytical applications. This stable isotope-labeled compound is essential for ensuring accurate quantification and method validation in complex biological matrices. It is a critical reagent for pharmaceutical research, forensic toxicology, and clinical laboratories engaged in drug metabolism and pharmacokinetic (DMPK) studies.

Application

• Quantitative Bioanalysis: Serves as a deuterated internal standard in LC-MS/MS and GC-MS methods for the precise measurement of triflupromazine and its metabolites in plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in preclinical and clinical research.
• Forensic Toxicology: Used as a reference standard in confirmatory testing for antipsychotic drugs in forensic investigations and workplace drug testing.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolite profiles to understand biotransformation pathways.
• Method Development and Validation: Critical for developing robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and assay validation of triflupromazine active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Triflupromazine Hydrochloride-D6
CAS No.	1416711-36-8
Molecular Formula	C18H13D6F3N2S • HCl
Molecular Weight	388.88 g/mol (approx.)
Synonyms	10-[3-(Dimethylamino)propyl]-2-(trifluoromethyl)phenothiazine-1,1,2,3,3,3-d6 Hydrochloride; Triflupromazine-d6 HCl; 2-Trifluoromethyl-10-[3-(dimethylamino)propyl]phenothiazine-d6 Hydrochloride; NSC 529051-d6; Vesprin-d6 Hydrochloride; Deuterated Triflupromazine HCl; Triflupromazine Internal Standard
EINECS	Contact for details

Quality Control

Our Triflupromazine Hydrochloride-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive mass spectrometry applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and related substances is provided.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.