Description

Pomalidomide-D4 (Deuterated) is a stable isotope-labeled analog of the immunomodulatory drug pomalidomide, where four hydrogen atoms are replaced with deuterium atoms. This compound is an essential internal standard for the precise quantification of pomalidomide in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical researchers, bioanalytical laboratories, and contract research organizations (CROs) engaged in drug metabolism, pharmacokinetic (DMPK) studies, and clinical trial support.

Application

• Bioanalytical Method Development and Validation: Serves as the primary internal standard for the accurate and reproducible quantification of pomalidomide in plasma, serum, and tissue samples.
• Pharmacokinetic (PK) and Toxicokinetic (TK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Research: Used in mass spectrometry-based assays to study metabolite profiles and metabolic pathways without isotopic interference.
• Clinical Trial Support: Critical for ensuring data integrity and regulatory compliance in bioanalysis for clinical phases of drug development.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating methods for the parent drug substance.

Basic Information

Product Name	Pomalidomide-D4 (Deuterated)
CAS No.	1416575-78-4
Molecular Formula	C₁₃H₇D₄N₃O₄
Molecular Weight	277.27 g/mol
Synonyms	4-Amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione-d4; (RS)-3-Amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione-d4; CC-4047-d4; Actimid-d4; Pomalyst-d4; Deuterated Pomalidomide; Pomalidomide (tetradeuterated)
EINECS	Contact for details

Quality Control

Our Pomalidomide-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive bioanalytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry standards for reference materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.