Description

Boc-Nh-Peg12-Ch2Ch2Cooh is a heterobifunctional polyethylene glycol (PEG) derivative featuring a tert-butyloxycarbonyl (Boc) protected amine at one terminus and a carboxylic acid at the other. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the controlled linkage of bioactive molecules, peptides, or surfaces. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, advanced drug delivery systems, and diagnostic reagent development.

Application

• Bioconjugation Reagent: For the site-specific coupling of peptides, proteins, or antibodies to drugs, surfaces, or other biomolecules.
• PEGylation Linker: Used to create PEGylated therapeutics to improve pharmacokinetics, solubility, and stability of active pharmaceutical ingredients (APIs).
• Drug Delivery System Development: As a functional spacer in the synthesis of prodrugs, antibody-drug conjugates (ADCs), and nanoparticle formulations.
• Diagnostic Assay Development: For immobilizing capture molecules (e.g., antibodies, antigens) onto sensor surfaces or microplates in immunoassays and biosensors.
• Material Science & Surface Modification: To introduce hydrophilic PEG layers onto materials, reducing non-specific binding and improving biocompatibility.
• Crosslinking Agent: In the preparation of hydrogels or polymer networks for tissue engineering and controlled release applications.

Basic Information

Product Name	Boc-Nh-Peg12-Ch2Ch2Cooh
CAS No.	1415981-79-1
Molecular Formula	C33H65NO16
Molecular Weight	731.86 g/mol
Synonyms	Boc-NH-PEG12-COOH; Boc-Amino-PEG12-Acid; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(Boc-amino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic Acid; tert-Butyl N-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate; Boc-15-amino-4,7,10,13-tetraoxapentadecanoic acid (PEG12 analog); Heterobifunctional PEG, Boc-NH-PEG-COOH; Boc-PEG12-acid
EINECS	Contact for details

Quality Control

Our Boc-Nh-Peg12-Ch2Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep containers in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.