Description

(4-((tert-Butoxycarbonyl)Amino)-2-Fluorophenyl)Boronic Acid is a high-value, multifunctional boronic acid derivative designed for advanced synthetic chemistry. Its core value lies in the strategic combination of a protected amine group and a boronic acid moiety, enabling precise cross-coupling reactions and serving as a versatile building block for complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, particularly for developing active pharmaceutical ingredients (APIs) and novel functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially for Suzuki-Miyaura cross-coupling reactions to form biaryl structures common in modern therapeutics.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors, leveraging the boronic acid group's ability to form reversible covalent bonds with enzyme active sites.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides that require fluorinated aromatic components for enhanced stability and bioavailability.
• Material Science & OLED Research: Employed in the creation of advanced organic electronic materials, where the fluorinated aromatic system contributes to charge transport and thermal stability.
• Bioconjugation & Probe Synthesis: Facilitates the development of fluorescent probes, biomarkers, and antibody-drug conjugates (ADCs) via its reactive boronic acid handle.
• Peptidomimetics & PROTACs: Integral to constructing peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) due to the protected Boc-amino group, allowing for further selective functionalization.

Basic Information

Item	Details
Product Name	(4-((tert-Butoxycarbonyl)Amino)-2-Fluorophenyl)Boronic Acid
CAS No.	1415960-56-3
Molecular Formula	C11H15BFNO4
Molecular Weight	255.05 g/mol
Synonyms	4-(Boc-amino)-2-fluorophenylboronic acid; 2-Fluoro-4-[(tert-butoxycarbonyl)amino]benzeneboronic acid; N-Boc-4-borono-3-fluoroaniline; (4-(tert-Butoxycarbonylamino)-2-fluorophenyl)boronic acid; Boc-4-borono-3-fluoroaniline; 2-Fluoro-4-[(tert-butoxycarbonyl)amino]phenylboronic acid; N-Boc-2-fluoro-4-boronobenzeneamine
EINECS	Contact for details

Quality Control

Our (4-((tert-Butoxycarbonyl)Amino)-2-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.