Description

1-(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrrolidine is a high-value, advanced pharmaceutical intermediate featuring a pyrrolidine-substituted aryl pinacol boronic ester. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex biaryl scaffolds. It is an essential building block for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity precursors for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a versatile boronic ester coupling partner to introduce the 3-fluoro-5-(pyrrolidin-1-yl)phenyl moiety into complex molecular architectures.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, ligands for catalysts, and fluorinated organic electronic materials.
• Chemical Biology & Probe Development: Useful for creating fluorescent tags, molecular probes, and other tools for biological imaging and target identification.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	1-(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrrolidine
CAS No.	1415928-84-5
Molecular Formula	C16H23BFNO2
Molecular Weight	291.17 g/mol
Synonyms	1-(3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine; 3-Fluoro-5-(pyrrolidin-1-yl)phenylboronic acid pinacol ester; (3-Fluoro-5-(pyrrolidin-1-yl)phenyl)boronic acid pinacol ester; 1-[3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine; 1415928-84-5; Boronic acid, B-[3-fluoro-5-(1-pyrrolidinyl)phenyl]-, 1,1-dimethylethyl ester; 1-(3-Fluoro-5-(pinacolatoboryl)phenyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our production of 1-(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrrolidine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. Each lot is characterized by advanced analytical techniques including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (argon or nitrogen) for long-term storage or after opening to maintain optimal purity and reactivity. Recommended storage temperature: 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.