Description

1-(2-Fluorobenzyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in its role as a versatile intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific fluorinated pyrazole motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in university and CRO (Contract Research Organization) laboratories.
• Ligand & Catalyst Development: Used to construct novel ligands for transition metal catalysis and organocatalysis.

Basic Information

Product Name	1-(2-Fluorobenzyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1415825-05-6
Molecular Formula	C16H22BFN2O2
Molecular Weight	304.17 g/mol
Synonyms	1-(2-Fluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(2-Fluorobenzyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(2-Fluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-fluorobenzyl)-1H-pyrazole; 1H-Pyrazole, 1-[(2-fluorophenyl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol 1-(2-Fluorobenzyl)-1H-pyrazole-4-boronate; 1-(2-Fluorobenzyl)pyrazole-4-boronic acid pinacol ester; CAS 1415825-05-6
EINECS	Contact for details

Quality Control

Our 1-(2-Fluorobenzyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications like pharmaceutical R&D. All products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.