Description

4-Phenoxy-2-(Trifluoromethyl)Phenylboronic Acid is a high-value, synthetically versatile boronic acid derivative. This compound matters as a critical building block in modern organic synthesis, particularly for the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing biaryl or heterobiaryl motifs with trifluoromethyl groups for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the phenoxy and trifluoromethyl groups contribute to biological activity and environmental persistence profiles.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of organic electronic materials, such as polymers for OLEDs or OFETs.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis or as a handle for constructing boron-containing sensor molecules.
• Chemical Biology Probes: Utilized in medicinal chemistry for the synthesis of tool compounds and probes targeting specific enzymes or biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CMOs for client-directed synthesis projects requiring this specific boronic acid coupling partner.

Basic Information

Product Name	4-Phenoxy-2-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1415824-99-5
Molecular Formula	C₁₃H₁₀BF₃O₃
Molecular Weight	282.03 g/mol
Synonyms	[4-Phenoxy-2-(trifluoromethyl)phenyl]boronic acid; 2-Trifluoromethyl-4-phenoxyphenylboronic acid; 4-Phenoxy-2-(trifluoromethyl)benzeneboronic acid; (4-Phenoxy-2-(trifluoromethyl)phenyl)boronic acid; Boronic acid, B-[4-phenoxy-2-(trifluoromethyl)phenyl]-; 1415824-99-5; 4-Phenoxy-α,α,α-trifluoro-o-tolylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Phenoxy-2-(Trifluoromethyl)Phenylboronic Acid undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive coupling reactions. Our quality commitment includes adherence to in-house specifications developed for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.