Description

Mal-Peg4-Pfp CAS NO 1415800-42-8 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and a pentafluorophenyl (Pfp) ester, designed for precise and efficient bioconjugation. This compound is critical for creating stable, site-specific linkages between thiol-containing biomolecules (like proteins or peptides) and amine-containing molecules under mild, aqueous conditions. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, antibody-drug conjugate (ADC) synthesis, and advanced diagnostic assay formulation, where controlled coupling is paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via thiol-maleimide chemistry.
• Protein-Polymer Conjugation: PEGylation of therapeutic proteins to enhance solubility, stability, and circulation half-life.
• Peptide Labeling & Modification: Introduction of fluorescent dyes, biotin, or other probes onto cysteine-containing peptides.
• Surface Functionalization: Immobilization of biomolecules onto amine-coated biosensors, chips, or nanoparticles for diagnostic applications.
• Hydrogel Formation: Cross-linking agent in the synthesis of biocompatible hydrogels for drug delivery and tissue engineering.
• Enzyme Immobilization: Covalent attachment of enzymes to solid supports while maintaining activity.
• Small Molecule Prodrug Synthesis: Creating cleavable linkages between targeting ligands and active pharmaceutical ingredients.

Basic Information

Product Name	Mal-Peg4-Pfp
CAS No.	1415800-42-8
Molecular Formula	C26H32F5NO10
Molecular Weight	613.53 g/mol
Synonyms	Maleimide-PEG4-PFP ester; 4-((((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)oxy)carbonyl)oxy)butyl 2,5-dioxopyrrolidin-1-yl 2,3,5,6-tetrafluorobenzene-1,4-dicarboxylate; PFP-PEG4-Maleimide; Pentafluorophenyl-PEG4-Maleimide; 1-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)oxy)-4-oxo-8,11,14-trioxa-5-azaheptadecan-17-oic acid 2,3,5,6-tetrafluoro-4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate; Maleimide-PEG4-PFP; Fmoc-PEG4-PFP (Note: This is a different, protected precursor); Heterobifunctional PEG crosslinker, Mal-PEG4-PFP
EINECS	Contact for details

Quality Control

Our Mal-Peg4-Pfp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or cGMP development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.