Description

Propargyl-Peg4-Acid is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a terminal alkyne (propargyl) group and a carboxylic acid. This compound is essential for creating stable, hydrophilic spacers in bioconjugation and materials science, enabling precise cross-linking via click chemistry and amide bond formation. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced polymer synthesis who require reliable, well-defined PEGylation agents.

Application

• Bioconjugation and ADC Development: Used as a hydrophilic linker to conjugate cytotoxic drugs to antibodies (Antibody-Drug Conjugates) or other targeting molecules, improving solubility and pharmacokinetics.
• Proteomics and Biomolecule Labeling: Facilitates site-specific labeling of proteins, peptides, and oligonucleotides via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Polymer and Materials Science: Serves as a functional monomer or cross-linker for synthesizing smart hydrogels, functionalized surfaces, and biocompatible materials with tailored properties.
• Diagnostic Reagent Synthesis: Employed in the construction of diagnostic probes and imaging agents where a stable, water-soluble linker is required between a recognition element and a signal moiety.
• Drug Delivery System Design: Incorporated into nanocarriers, liposomes, and micelles to provide functional handles for attaching targeting ligands or therapeutic payloads.
• Chemical Biology Tool Development: A key building block for creating activity-based probes and other chemical tools to study biological processes in living systems.

Basic Information

Product Name	Propargyl-Peg4-Acid
CAS No.	1415800-32-6
Molecular Formula	C16H26O8
Molecular Weight	346.37 g/mol
Synonyms	Propargyl-PEG4-acid; 17-Prop-2-yn-1-yloxy-3,6,9,12-tetraoxaheptadecan-1-oic acid; Propargyl-O-(CH2CH2O)4-CH2COOH; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-prop-2-yn-1-yloxy-; Propargyl-PEG4-COOH; Alkyne-PEG4-acid; Propargyl tetraethylene glycol carboxylic acid; 4,7,10,13-Tetraoxahexadec-15-ynoic acid
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) with detailed specifications are provided to ensure the material meets the rigorous standards required for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Acid Value (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.