Description

2-Bromo-3-Amino-6-Fluorobenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromo, amino, and fluoro substituents on a benzonitrile core, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Serves as a critical building block for developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorine and bromine substituents.
• Material Science Research: Used in the development of advanced organic materials, including liquid crystals, organic semiconductors, and functional polymers.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig) to create complex biaryl and heteroaryl structures.
• Chemical Derivatization: The reactive amino and cyano groups allow for further functionalization to amides, imines, heterocycles, and other nitrogen-containing compounds.

Basic Information

Product Name	2-Bromo-3-Amino-6-Fluorobenzonitrile
CAS No.	1415633-90-7
Molecular Formula	C7H4BrFN2
Molecular Weight	215.02 g/mol
Synonyms	2-Bromo-3-amino-6-fluorobenzonitrile; 3-Amino-2-bromo-6-fluorobenzonitrile; 6-Fluoro-3-amino-2-bromobenzonitrile; Benzonitrile, 2-bromo-3-amino-6-fluoro-; 2-Bromo-6-fluoro-3-aminobenzonitrile; 1415633-90-7; AI3-52313
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Amino-6-Fluorobenzonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.