Description

3-Fluoro-5-Trifluoromethylthioanisole is a high-value fluorinated aromatic building block, distinguished by its unique combination of fluorine and trifluoromethylthioether functional groups. This compound is critical for introducing lipophilicity and metabolic stability into advanced molecular architectures, making it a sought-after intermediate in modern synthetic chemistry. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by specialty chemical manufacturers producing advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for CNS and oncology targets, where its fluorinated structure can enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where the trifluoromethylthio group contributes to improved pesticidal activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Material Research: Employed in academic and industrial labs for developing novel polymers, ligands, and specialty chemicals with tailored electronic and surface properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to construct complex biaryl systems.

Basic Information

Product Name	3-Fluoro-5-Trifluoromethylthioanisole
CAS No.	1414870-73-7
Molecular Formula	C8H4F4S
Molecular Weight	208.18 g/mol
Synonyms	1-Fluoro-3-[(trifluoromethyl)sulfanyl]-5-methoxybenzene; 3-Fluoro-5-(trifluoromethylthio)anisole; 5-Methoxy-3-[(trifluoromethyl)thio]fluorobenzene; 1-Methoxy-3-fluoro-5-(trifluoromethylthio)benzene; 3-Fluoro-5-(trifluoromethylsulfanyl)anisole; Benzene, 1-fluoro-3-[(trifluoromethyl)thio]-5-methoxy-; 3-Fluoro-5-(trifluoromethylmercapto)anisole
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-5-Trifluoromethylthioanisole is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications developed for high-purity organic intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.