Description

n-(9-Deoxy-Epi-Cinchonidin-9-Yl)Picolinamide is a high-purity, advanced pharmaceutical intermediate derived from cinchona alkaloid chemistry. This compound is valued for its role as a key chiral building block in the synthesis of complex organic molecules, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in asymmetric synthesis, catalysis, and the production of specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Catalysis: Serves as a ligand precursor or a structural component in the design of chiral catalysts for enantioselective reactions.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for developing new synthetic methodologies and exploring structure-activity relationships.
• Fine Chemical Production: Employed in the manufacture of high-value, complex specialty chemicals requiring specific stereochemistry.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	n-(9-Deoxy-Epi-Cinchonidin-9-Yl)Picolinamide
CAS No.	1414851-57-2
Molecular Formula	C22H23N3O
Molecular Weight	345.44 g/mol
Synonyms	9-Deoxy-9-epi-cinchonidin-9-yl picolinamide; (9R)-9-Deoxy-9-epi-cinchonidin-9-yl picolinamide; Picolinamide, N-(9-deoxy-9-epi-cinchonidin-9-yl)-; Cinchonidine derivative; Chiral cinchona alkaloid amide; Asymmetric synthesis intermediate
EINECS	Contact for details

Quality Control

Our n-(9-Deoxy-Epi-Cinchonidin-9-Yl)Picolinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and relevant ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged operations to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.