Description

[(2,2-Difluoro-Ethylcarbamoyl)-Methyl]-Carbamic Acid tert-Butyl Ester is a high-value, protected amino acid derivative and a critical building block in advanced organic synthesis. This compound is essential for the development of novel pharmaceutical intermediates, particularly in the synthesis of complex molecules containing fluorinated motifs. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing peptide analogs and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated peptide-based drug candidates and protease inhibitors.
• Agrochemical Synthesis: Used in the research and development of novel, fluorinated active ingredients for crop protection.
• Peptide Chemistry: Serves as a protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific, protected fluorinated building blocks.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry for exploring structure-activity relationships (SAR).

Basic Information

Product Name	[(2,2-Difluoro-Ethylcarbamoyl)-Methyl]-Carbamic Acid tert-Butyl Ester
CAS No.	1414642-52-6
Molecular Formula	C9H16F2N2O3
Molecular Weight	238.23 g/mol
Synonyms	N-[(tert-Butoxycarbonyl)amino]acetyl-2,2-difluoroethylamine; Boc-NH-CH2-C(O)-NH-CH2-CF2H; tert-Butyl N-[(2,2-difluoroethylcarbamoyl)methyl]carbamate; 2,2-Difluoro-N-[(2-{[(tert-butoxy)carbonyl]amino}acetyl)ethyl]amine; BOC-Glycine-2,2-difluoroethylamide; (Boc-Gly)-2,2-difluoroethylamide; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, 2,2-difluoroethylamide
EINECS	Contact for details

Quality Control

Our [(2,2-Difluoro-Ethylcarbamoyl)-Methyl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.