Description

Ticagrelor Related Compound 5 is a high-purity chemical reference standard, identified by CAS No. 1414348-35-8, used in the analytical profiling of the active pharmaceutical ingredient Ticagrelor. This compound is critical for ensuring the quality, safety, and efficacy of Ticagrelor-based drug products by serving as a known impurity or degradation product marker. It is an essential material for pharmaceutical R&D and quality control laboratories focused on cardiovascular therapeutics.

Application

• Pharmaceutical Impurity Profiling: Used as a certified reference standard for the identification and quantification of specific impurities in Ticagrelor API and finished dosage forms.
• Analytical Method Development & Validation: Serves as a critical component in developing and validating HPLC, UPLC, or LC-MS methods for Ticagrelor analysis.
• Stability Studies: Employed as a marker to monitor degradation pathways and establish shelf-life specifications for Ticagrelor products.
• Regulatory Compliance & Submission: Provides essential data for regulatory filings (e.g., FDA, EMA) to demonstrate thorough impurity characterization and control.
• Quality Control Testing: Used in routine QC release testing of Ticagrelor batches to ensure compliance with pharmacopeial limits (e.g., USP, EP).
• Research on Degradation Chemistry: Facilitates studies on the formation mechanisms and toxicological significance of this related compound.

Basic Information

Product Name	Ticagrelor Related Compound 5
CAS No.	1414348-35-8
Molecular Formula	C23H28F2N6O4S
Molecular Weight	522.57 g/mol
Synonyms	BRILINTA Related Compound 5; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol; Ticagrelor Impurity 5; Ticagrelor EP Impurity G; Ticagrelor USP Related Compound 5; AZD6140 Related Compound 5
EINECS	Contact for details

Quality Control

Every batch of Ticagrelor Related Compound 5 is manufactured and analyzed under strict quality systems. Our products undergo rigorous identity, purity, and impurity profile testing using advanced techniques like HPLC and LC-MS to ensure compliance with pharmacopeial and internal specifications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual unknown impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.