Description

Ivacaftor-D18 CAS NO 1413431-05-6 is a deuterated isotopologue of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator Ivacaftor, where eighteen hydrogen atoms are replaced with deuterium. This deuteration is strategically employed to alter the pharmacokinetic profile, primarily to extend the metabolic half-life and reduce the formation of potentially reactive metabolites. It is a critical material for pharmaceutical research and development, specifically in the areas of drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and as a certified reference standard. Professionals in pharmaceutical R&D, contract research organizations (CROs), and analytical laboratories require this high-purity compound for advanced studies.

Application

• Internal Standard for Bioanalysis: Serves as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Ivacaftor in biological matrices like plasma and serum.
• Drug Metabolism Studies (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) research to investigate the metabolic pathways and pharmacokinetics of Ivacaftor.
• Mass Spectrometry Reference Standard: Provides a definitive reference for method validation, calibration, and ensuring accuracy in mass spectrometric analyses.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of deuterated-related substances or metabolites during drug substance and product development.
• Clinical Research Support: Employed in clinical trial sample analysis to ensure reliable and reproducible data on drug concentration levels.
• Stable Isotope Tracer Studies: Facilitates mechanistic studies on the fate of the Ivacaftor molecule in vitro and in vivo systems.

Basic Information

Product Name	Ivacaftor-D18
CAS No.	1413431-05-6
Molecular Formula	C24H10D18N2O3
Molecular Weight	406.55 g/mol (approximate)
Synonyms	N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide-d18; VX-770-d18; Kalydeco-d18; Ivacaftor (phenyl-d5, tert-butyl-d9); 1,4-Dihydro-4-oxo-N-[5-(1,1,1,3,3,3-hexadeuterio-2-methylpropan-2-yl)-2-(2,2,3,3,3-pentadeuteriopropan-2-yl)phenyl]-1,8-naphthyridine-3-carboxamide; Deuterated Ivacaftor; Ivacaftor-d18 Isotope; CFTR Potentiator-d18.
EINECS	Contact for details

Quality Control

Our Ivacaftor-D18 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Each batch is characterized by advanced techniques including NMR (Nuclear Magnetic Resonance) and High-Resolution Mass Spectrometry (HRMS) to confirm deuteration level and structural integrity. We provide comprehensive Certificates of Analysis (COA) detailing purity (typically ≥98% by HPLC), isotopic enrichment (≥98 atom % D), and other critical specifications. Our quality system is designed to support GMP/GLP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.