Description

(S)-2-(Pyrrolidin-2-Yl)Acetonitrile Hydrochloride is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in the critical (S)-pyrrolidine scaffold, which is a privileged structural motif in medicinal chemistry. This compound is essential for researchers and manufacturers developing pharmaceuticals, particularly in the creation of novel active pharmaceutical ingredients (APIs) and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of drug candidates targeting neurological disorders, cardiovascular diseases, and other therapeutic areas.
• Asymmetric Synthesis: Used as a precursor for chiral ligands, catalysts, and auxiliaries in stereoselective chemical transformations.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing complex molecular libraries in drug discovery and lead optimization programs.
• Agrochemical Development: Employed in the research and synthesis of advanced, chiral active ingredients for crop protection.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	(S)-2-(Pyrrolidin-2-Yl)Acetonitrile Hydrochloride
CAS No.	1413085-67-2
Molecular Formula	C6H11ClN2
Molecular Weight	146.62 g/mol
Synonyms	(S)-2-(2-Pyrrolidinyl)acetonitrile hydrochloride; (S)-2-(Pyrrolidin-2-yl)ethanenitrile hydrochloride; (S)-2-Cyanomethylpyrrolidine hydrochloride; (S)-1-(Cyanomethyl)pyrrolidinium chloride; (S)-Pyrrolidine-2-acetonitrile hydrochloride; (2S)-2-(2-Pyrrolidinyl)acetonitrile hydrochloride; (S)-2-Pyrrolidineacetonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-(Pyrrolidin-2-Yl)Acetonitrile Hydrochloride is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for every batch, detailing purity, chiral purity, and impurity profiles. Our quality commitment aligns with the standards required for GMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.