Description

Asenapine Citrate CAS NO 1411867-74-7 is the citrate salt form of asenapine, a high-purity active pharmaceutical ingredient (API) belonging to the dibenzoxepino pyrrole class. This compound is critical for ensuring the efficacy and batch-to-batch consistency of final pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of antipsychotic medications.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the manufacture of antipsychotic drugs.
• Key component in the formulation of sublingual tablets and other dosage forms for the treatment of schizophrenia and bipolar I disorder.
• Utilized in pharmaceutical research and development for studying novel drug delivery systems.
• Reference standard in analytical laboratories for quality control and method validation (HPLC, LC-MS).
• Used in preclinical and clinical studies to investigate pharmacological profiles.
• Serves as a starting material or intermediate for the synthesis of related chemical entities in medicinal chemistry.

Basic Information

Product Name	Asenapine Citrate
CAS No.	1411867-74-7
Molecular Formula	C24H28ClN3O2 • C6H8O7
Molecular Weight	Contact for details
Synonyms	trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole citrate; Asenapine citrate salt; Asenapine hydrogen citrate; SAPHRIS (trade name for formulated product); Org 5222 citrate; (3aR,12bR)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole citrate
EINECS	Contact for details

Quality Control

Our Asenapine Citrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting compliance with relevant standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.