Description

Boc-L-Dbu(Fmoc)-Oh is a protected amino acid derivative, specifically an orthogonally protected diaminobutyric acid (Dbu) building block, essential for modern solid-phase peptide synthesis (SPPS). Its dual protection scheme, featuring a base-labile Fmoc group and an acid-labile Boc group, provides exceptional versatility and control in constructing complex peptide sequences. This high-purity intermediate is critical for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of peptides using Fmoc-chemistry protocols.
• Pharmaceutical Research & Development: Used in the synthesis of novel peptide drug candidates, including antimicrobial peptides and hormone analogs.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or reporter groups.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Tool Development: Integral for creating labeled peptides, enzyme substrates, and inhibitors for proteomics and enzymology studies.
• Material Science: Can be incorporated into peptide-based polymers and biomaterials for specialized applications.

Basic Information

Product Name	Boc-L-Dbu(Fmoc)-Oh
CAS No.	1409939-21-4
Molecular Formula	C25H30N2O6
Molecular Weight	454.52 g/mol
Synonyms	Nα-Boc-Nδ-Fmoc-L-2,4-diaminobutyric acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid; Boc-Dbu(Fmoc)-OH; Fmoc-Dbu(Boc)-OH; Boc-L-2,4-diaminobutyric acid(Fmoc)-OH; L-Dbu(Boc,Fmoc)-OH; N-Boc-N'-Fmoc-L-diaminobutyric acid
EINECS	Contact for details

Quality Control

Our Boc-L-Dbu(Fmoc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for critical research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.