Description

Potassium Trifluoro(2-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Ethyl)Borate is a specialized organoboron reagent featuring a protected alcohol moiety. This compound is valued for its role as a stable and versatile building block in advanced synthetic chemistry, particularly in the formation of carbon-boron bonds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron reagent for the palladium-catalyzed formation of carbon-carbon bonds, a cornerstone of modern medicinal chemistry.
• Pharmaceutical Intermediate Synthesis: Used in the multi-step synthesis of complex drug candidates, leveraging the THP-protected alcohol for selective deprotection and further functionalization.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides where specific boron-containing scaffolds are required.
• Material Science Precursor: Acts as a precursor for boron-doped organic materials and polymers with tailored electronic or optical properties.
• Asymmetric Synthesis: The chiral center of the tetrahydro-2H-pyran ring can be exploited in stereoselective transformations to create enantiomerically enriched compounds.
• Process Chemistry & Scale-Up: Its stability makes it suitable for optimization and scaling in pilot plant and manufacturing environments for commercial production.

Basic Information

Product Name	Potassium Trifluoro(2-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Ethyl)Borate
CAS No.	1408168-76-2
Molecular Formula	C7H11BF3KO2
Molecular Weight	234.07 g/mol
Synonyms	Potassium (2-((Tetrahydro-2H-pyran-2-yl)oxy)ethyl)trifluoroborate; 2-((Tetrahydro-2H-pyran-2-yl)oxy)ethyltrifluoroborate Potassium Salt; Potassium 2-(Tetrahydro-2H-pyran-2-yloxy)ethyltrifluoroborate; THP-Protected Hydroxyethyltrifluoroborate Potassium Salt; (2-(Tetrahydro-2H-pyran-2-yloxy)ethyl)potassium trifluoroborane; Potassium (2-(Tetrahydro-2H-pyran-2-yloxy)ethyl)trifluoroboranuide
EINECS	Contact for details

Quality Control

Our Potassium Trifluoro(2-((Tetrahydro-2H-Pyran-2-Yl)Oxy)Ethyl)Borate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B) and HPLC analysis, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
¹H NMR Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.