Description

1-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)-4-Methylpiperazine is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group, making it a critical building block for modern drug discovery. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures prevalent in active pharmaceutical ingredients (APIs). This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel therapeutics and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those containing fluorinated biaryl motifs for enhanced metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation with aryl halides, enabling the construction of diverse chemical libraries.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or molecular sensors, where the piperazine and boronate groups modify electronic properties.
• Chemical Biology & Proteolysis-Targeting Chimeras (PROTACs): Acts as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and process development projects.

Basic Information

Product Name	1-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)-4-Methylpiperazine
CAS No.	1408088-34-5
Molecular Formula	C17H26BFNO2
Molecular Weight	305.21 g/mol
Synonyms	4-Methyl-1-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine; 1-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-4-methylpiperazine; 2-Fluoro-4-(4-methylpiperazin-1-yl)phenylboronic acid pinacol ester; 4-Methyl-1-(2-fluoro-4-(pinacolboranyl)phenyl)piperazine; 1408088-34-5; 1-(2-Fluoro-4-(pinacolboronato)phenyl)-4-methylpiperazine
EINECS	Contact for details

Quality Control

Our 1-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)-4-Methylpiperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity suitable for sensitive cross-coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of pharmaceutical R&D and cGMP starting material guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) when possible to maintain stability and prevent hydrolysis of the boronic ester moiety. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.