Description

8-Boc-2-Oxo-8-Azabicyclo[3.2.1]Octane is a high-purity, protected bicyclic lactam building block of significant interest in advanced organic synthesis. Its core value lies in providing a rigid, functionalized scaffold that is critical for constructing complex nitrogen-containing heterocycles, a key structural motif in modern pharmaceuticals. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of tropane alkaloid analogs and other bioactive molecules.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing focused libraries in drug discovery, particularly for neurological targets.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Acts as a building block for developing novel pesticides and herbicides with complex stereochemistry.
• Academic Research: Utilized in methodological studies for novel ring-forming reactions and asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing specialized intermediates for clients.

Basic Information

Product Name	8-Boc-2-Oxo-8-Azabicyclo[3.2.1]Octane
CAS No.	1408076-39-0
Molecular Formula	C₁₂H₁₉NO₃
Molecular Weight	225.28 g/mol
Synonyms	8-[(tert-Butoxycarbonyl)-2-oxo-8-azabicyclo[3.2.1]octane; tert-Butyl 2-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate; 8-Boc-8-azabicyclo[3.2.1]octan-2-one; 8-Azabicyclo[3.2.1]octan-2-one, 8-[(1,1-dimethylethoxy)carbonyl]-; Bicyclo[3.2.1]octan-2-one, 8-[(tert-butoxycarbonyl)-8-aza-; 8-Boc-2-azabicyclo[3.2.1]octan-3-one (common misnomer); 8-Boc-tropinone
EINECS	Contact for details

Quality Control

Our 8-Boc-2-Oxo-8-Azabicyclo[3.2.1]Octane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete chromatographic and spectroscopic data are provided for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.