Description

(3,3-Difluoro-1-Methyl-Cyclobutyl)Methanol is a high-value fluorinated cyclobutane derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a difluorinated cyclobutyl ring, is engineered to modulate the physicochemical properties and metabolic stability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients where fluorine substitution is strategically employed.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small-molecule drugs, especially protease inhibitors, kinase inhibitors, and other therapeutics where the difluorocyclobutyl moiety enhances potency and pharmacokinetic profiles.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can improve biological activity, environmental stability, and selectivity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science Research: Investigated as a monomer or modifier for specialty polymers and coatings, leveraging the cyclobutane ring for rigidity and fluorine for unique surface properties.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and the stereoelectronic effects of gem-difluoro groups on adjacent functional groups.

Basic Information

Product Name	(3,3-Difluoro-1-Methyl-Cyclobutyl)Methanol
CAS No.	1408076-35-6
Molecular Formula	C6H10F2O
Molecular Weight	136.14 g/mol
Synonyms	(3,3-Difluoro-1-methylcyclobutyl)methanol; 1-Methyl-3,3-difluorocyclobutane-1-methanol; (1-Methyl-3,3-difluorocyclobutyl)methanol; 3,3-Difluoro-1-methylcyclobutylmethanol; (3,3-Difluoro-1-methyl-cyclobutyl)-methanol; 1408076-35-6; SCHEMBL23385077
EINECS	Contact for details

Quality Control

Our (3,3-Difluoro-1-Methyl-Cyclobutyl)Methanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure high chemical and isomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.