Description

cis-3-Fluorocyclobutanamine Hydrochloride is a high-purity, organofluorine building block essential for modern pharmaceutical and agrochemical research. This compound is valued for its unique structural motif, which introduces both conformational rigidity and fluorine's beneficial electronic properties into target molecules. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs) and candidates for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used as a building block for creating advanced pesticides and herbicides, where the fluorinated cyclobutane ring can enhance biological activity and environmental stability.
• Chemical Biology & Proteomics: Serves as a versatile handle for labeling studies, activity-based protein profiling (ABPP), and the development of molecular probes.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced materials with tailored properties.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) settings for methodological development and exploring new chemical spaces in synthetic organic chemistry.

Basic Information

Product Name	cis-3-Fluorocyclobutanamine Hydrochloride
CAS No.	1408075-13-7
Molecular Formula	C4H9ClFN
Molecular Weight	125.57 g/mol
Synonyms	cis-3-Fluorocyclobutan-1-amine hydrochloride; (1s,3s)-3-Fluorocyclobutan-1-amine hydrochloride; 3-Fluorocyclobutanamine HCl (cis-); 3-Fluoro-cis-cyclobutanamine hydrochloride; 1408075-13-7; FCB Amine HCl; 3-Fluorocyclobutylamine hydrochloride (cis-)
EINECS	Contact for details

Quality Control

Our cis-3-Fluorocyclobutanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (cis- isomer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.