Description

3-Amino-1-Boc-4,4-difluoropyrrolidine is a high-value, protected pyrrolidine derivative featuring both a Boc-protected amine and a gem-difluoro motif. This compound serves as a critical chiral building block in modern pharmaceutical and agrochemical research, enabling the synthesis of complex molecules with enhanced metabolic stability and bioavailability. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents, leveraging the difluoro group to influence lipophilicity and biological activity.
• Peptidomimetics: Incorporation into peptide backbones to create stable analogs resistant to enzymatic degradation.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds and probes to study biological pathways.
• Material Science: Potential monomer or precursor for specialty polymers and advanced materials.

Basic Information

Product Name	3-Amino-1-Boc-4,4-difluoropyrrolidine
CAS No.	1408074-83-8
Molecular Formula	C9H16F2N2O2
Molecular Weight	222.23 g/mol
Synonyms	1-Boc-3-amino-4,4-difluoropyrrolidine; tert-Butyl 3-amino-4,4-difluoropyrrolidine-1-carboxylate; 4,4-Difluoro-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester; 3-Amino-4,4-difluoropyrrolidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4,4-difluoro-3-aminopyrrolidine; 4,4-Difluoro-3-aminopyrrolidine, N-Boc protected; BOC-3-Amino-4,4-difluoropyrrolidine
EINECS	Contact for details

Quality Control

Our 3-Amino-1-Boc-4,4-difluoropyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.