Description

4-Ethynyl-2,2-Difluoro-1,3-Benzodioxole is a high-value, multi-functional fluorinated aromatic building block featuring a reactive ethynyl group. This compound is critical for advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of novel herbicides and fungicides with enhanced activity and environmental profiles.
• Material Science: Serves as a monomer or cross-linker in the synthesis of specialty polymers, resins, and advanced organic frameworks (MOFs/COFs).
• Ligand & Catalyst Development: Employed to create novel phosphine or N-heterocyclic carbene (NHC) ligands for transition metal catalysis.
• Fluorescent Probe & Dye Chemistry: The conjugated system is utilized in the design of fluorophores and molecular sensors.
• Academic & R&D: A versatile reagent for methodological studies in synthetic organic chemistry, including Sonogashira and Click chemistry.

Basic Information

Product Name	4-Ethynyl-2,2-Difluoro-1,3-Benzodioxole
CAS No.	1408074-62-3
Molecular Formula	C9H4F2O2
Molecular Weight	182.13 g/mol
Synonyms	4-Ethynyl-2,2-difluorobenzo[d][1,3]dioxole; 2,2-Difluoro-4-ethynyl-1,3-benzodioxole; 4-Ethynyl-2,2-difluoro-1,3-benzodioxole; 1,3-Benzodioxole, 4-ethynyl-2,2-difluoro-; 1408074-62-3; 4-Ethynyl-2,2-difluorobenzo-1,3-dioxole
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-2,2-Difluoro-1,3-Benzodioxole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.