Description

(2R)-1-Boc-2-Methylpyrrolidine-2-Methanamine CAS NO 1407997-78-7 is a high-purity, chiral pyrrolidine derivative featuring a Boc-protected amine and a primary amine side chain, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in providing a stereochemically defined, multifunctional scaffold essential for constructing complex bioactive molecules, particularly in medicinal chemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including protease inhibitors, kinase inhibitors, and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce specific stereochemistry and functional groups.
• Protease Inhibitor Synthesis: Core scaffold in the development of inhibitors for various proteolytic enzymes.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Peptidomimetic Development: Integral for creating stable, drug-like molecules that mimic peptide structures.
• Chemical Biology Probes: Useful for creating labeled compounds to study biological pathways and target engagement.

Basic Information

Product Name	(2R)-1-Boc-2-Methylpyrrolidine-2-Methanamine
CAS No.	1407997-78-7
Molecular Formula	C12H24N2O2
Molecular Weight	228.33 g/mol
Synonyms	(2R)-2-(Aminomethyl)-1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine; (R)-1-Boc-2-(aminomethyl)-2-methylpyrrolidine; (R)-1-(tert-Butoxycarbonyl)-2-(aminomethyl)-2-methylpyrrolidine; tert-Butyl (2R)-2-(aminomethyl)-2-methylpyrrolidine-1-carboxylate; (2R)-1-Boc-2-methylpyrrolidine-2-methanamine; (R)-2-Methyl-1-Boc-pyrrolidine-2-methanamine; BOC-(R)-2-Methylpyrrolidine-2-methanamine
EINECS	Contact for details

Quality Control

Our (2R)-1-Boc-2-Methylpyrrolidine-2-Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.