Description

Dolutegravir-D6 CAS NO 1407166-95-3 is a deuterated isotopologue of the HIV integrase strand transfer inhibitor Dolutegravir, where six hydrogen atoms are replaced by the stable isotope deuterium. This compound is a critical internal standard used in quantitative bioanalytical methods, ensuring the accuracy and reliability of pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control units involved in the development and manufacture of antiretroviral therapies.

Application

• Primary use as an Internal Standard for the precise quantification of Dolutegravir in biological matrices (e.g., plasma, serum) via LC-MS/MS and GC-MS.
• Metabolite identification and profiling studies in drug metabolism and pharmacokinetics (DMPK) research.
• Method development and validation for bioanalytical assays in support of clinical trials and regulatory submissions.
• Quality control and batch release testing in the pharmaceutical manufacturing of Dolutegravir-based drug products.
• Stability-indicating assay development to monitor drug degradation and ensure product shelf-life.
• Use in forensic and anti-doping analysis for the accurate detection of the parent compound.

Basic Information

Product Name	Dolutegravir-D6
CAS No.	1407166-95-3
Molecular Formula	C20H13D6F2N3O5
Molecular Weight	425.41 g/mol
Synonyms	Dolutegravir-d6; (4R,12aS)-4-(Dideutero(2,4-difluorophenyl)methyl)-9-hydroxy-7-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-2-carboxamide-3,3,4,4,5,5-d6; S/GSK1349572-d6; GSK1349572-d6; Tivicay-d6 (deuterated); DTG-d6; HIV integrase inhibitor-d6 (deuterated)
EINECS	Contact for details

Quality Control

Our Dolutegravir-D6 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, chemical purity, and isotopic enrichment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on assay, deuterium content, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.