Description

5-(tert-Butoxycarbonylamino)-4,4-Difluoro-2-Methylpentanoic Acid is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a difluoromethyl-substituted side chain. This compound serves as a critical building block in modern organic synthesis, enabling the precise introduction of fluorinated motifs and protected amine functionalities into target molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated peptides, peptidomimetics, and active pharmaceutical ingredients (APIs) targeting metabolic and central nervous system diseases.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in constructing the linker or ligand components of bifunctional molecules designed for targeted protein degradation.
• Agrochemical Research: Serves as a precursor for novel fluorinated agrochemicals, where the difluoro group can enhance metabolic stability and bioavailability.
• Fluorine Chemistry & Material Science: Employed in academic and industrial research to explore the effects of fluorination on molecular properties for advanced material applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex, custom-specified molecules under cGMP or research-grade conditions.

Basic Information

Product Name	5-(tert-Butoxycarbonylamino)-4,4-Difluoro-2-Methylpentanoic Acid
CAS No.	1404196-60-6
Molecular Formula	C12H21F2NO4
Molecular Weight	281.30 g/mol
Synonyms	Boc-4,4-Difluoro-2-methylnorvaline; 4,4-Difluoro-2-methyl-5-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid; 5-[(tert-Butoxycarbonyl)amino]-4,4-difluoro-2-methylpentanoic acid; N-Boc-4,4-difluoro-2-methylnorvaline; 4,4-Difluoro-2-methyl-N-[(2-methylpropan-2-yl)oxycarbonyl]norvaline; Boc-Difluoro-methyl-norvaline-OH; (R/S)-5-(tert-Butoxycarbonylamino)-4,4-difluoro-2-methylpentanoic acid (racemic mixture)
EINECS	Contact for details

Quality Control

Our production of 5-(tert-Butoxycarbonylamino)-4,4-Difluoro-2-Methylpentanoic Acid adheres to stringent internal quality standards, ensuring batch-to-batch consistency for research and development applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development projects requiring material produced under GMP-like controls for non-clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under dry, inert conditions for long-term storage to prevent degradation. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.