Description

Di-tert-Butyl 4,4'-Azanediyldipiperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of complex molecules, particularly in the creation of kinase inhibitors and other targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel oncology and anti-inflammatory treatments.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sophisticated active pharmaceutical ingredients (APIs), especially for kinase-targeted drugs.
• Drug Discovery & Medicinal Chemistry: Used in research and development for constructing molecular scaffolds with specific biological activity.
• Chemical Biology Probes: Employed in the development of tool compounds for studying enzyme function and cellular signaling pathways.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot and commercial production scales.

Basic Information

Product Name	Di-tert-Butyl 4,4'-Azanediyldipiperidine-1-Carboxylate
CAS No.	1404196-18-4
Molecular Formula	C24H44N4O4
Molecular Weight	452.63 g/mol
Synonyms	1,1'-[(4-Amino-1-piperidinyl)imino]bis[2,2-dimethyl-1-propanol] di-tert-butyl ester; 4,4'-(Piperazine-1,4-diyl)dipiperidine-1-carboxylic acid di-tert-butyl ester; Di-tert-butyl 4,4'-(piperazine-1,4-diyl)dipiperidine-1-carboxylate; 4,4'-Azanediyldipiperidine-1-carboxylic acid di-tert-butyl ester; BOC-Piperazine-Piperidine; tert-Butyl 4-[4-(1-tert-butoxycarbonylpiperidin-4-yl)piperazin-1-yl]piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our Di-tert-Butyl 4,4'-Azanediyldipiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.