Description

1-Chloro-4-(Difluoromethoxy)-2-Fluoro-Benzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring chloro, fluoro, and difluoromethoxy substituents, makes it a critical intermediate for the development of complex molecules. This compound is primarily sought by pharmaceutical and agrochemical R&D teams for constructing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where its fluorine content can modify material properties like chemical resistance and dielectric constant.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce functionalized aryl groups.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination methodologies and the effects of polyfluorinated motifs on molecular conformation.

Basic Information

Item	Detail
Product Name	1-Chloro-4-(Difluoromethoxy)-2-Fluoro-Benzene
CAS No.	1404194-91-7
Molecular Formula	C7H4ClF3O
Molecular Weight	196.56 g/mol
Synonyms	2-Fluoro-1-chloro-4-(difluoromethoxy)benzene; 4-Chloro-3-fluoroanisole, 2',4'-difluoro; 1-Chloro-2-fluoro-4-(difluoromethoxy)benzene; Benzene, 1-chloro-4-(difluoromethoxy)-2-fluoro-; DFMFB (abbreviation); 3-Fluoro-4-chlorophenyl difluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-(Difluoromethoxy)-2-Fluoro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.