Description

2,4-Difluoro-1-(Trifluoromethoxy)Benzene is a high-value fluorinated aromatic building block, essential for introducing both fluorine and trifluoromethoxy substituents into complex molecular architectures. Its unique structure makes it a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where these functional groups are prized for their ability to modulate lipophilicity, metabolic stability, and electronic properties. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating next-generation products.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in CNS, anti-inflammatory, and oncology research, where the difluoro and trifluoromethoxy motifs enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging fluorine's ability to improve pesticidal activity, photostability, and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved dielectric anisotropy, thermal stability, and electron transport properties.
• Polymer & Specialty Chemicals: Incorporated into high-performance polymers, coatings, and surfactants to impart chemical resistance, low surface energy, and enhanced durability.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reactions in fluorination chemistry and as a standard in analytical method development.

Basic Information

Product Name	2,4-Difluoro-1-(Trifluoromethoxy)Benzene
CAS No.	1404194-72-4
Molecular Formula	C7H3F5O
Molecular Weight	198.09 g/mol
Synonyms	1-(Trifluoromethoxy)-2,4-difluorobenzene; 2,4-Difluorophenyl trifluoromethyl ether; Benzene, 2,4-difluoro-1-(trifluoromethoxy)-; α,α,α-Trifluoro-2,4-difluoroanisole; Trifluoromethyl 2,4-difluorophenyl ether
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-1-(Trifluoromethoxy)Benzene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from heat sources and open flame. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.