Description

1-(Difluoromethoxy)-2,3-Difluoro-Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique difluoromethoxy and difluoro substitution pattern makes it a valuable precursor for introducing fluorine atoms into complex molecular architectures, which is critical for modulating the physicochemical and biological properties of target compounds. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability, lipophilicity, and overall efficacy.
• Liquid Crystal & OLED Materials: Serves as a fluorinated core structure in the synthesis of specialty chemicals for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer & Material Science: Employed as a monomer or modifier to create fluorinated polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic substitutions, and other transformations to construct complex, fluorinated molecules for various R&D purposes.

Basic Information

Product Name	1-(Difluoromethoxy)-2,3-Difluoro-Benzene
CAS No.	1404194-70-2
Molecular Formula	C7H4F4O
Molecular Weight	180.10 g/mol
Synonyms	2,3-Difluoro-1-(difluoromethoxy)benzene; Benzene, 1-(difluoromethoxy)-2,3-difluoro-; 2,3-Difluorophenyl difluoromethyl ether; 1-(Difluoromethoxy)-2,3-difluorobenzene; Difluoromethoxy-2,3-difluorobenzene
EINECS	Contact for details

Quality Control

Every batch of 1-(Difluoromethoxy)-2,3-Difluoro-Benzene is manufactured and analyzed under strict quality management protocols to ensure consistency and high purity suitable for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flames. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.