Description

4-Chloro-2-(Difluoromethoxy)-1-Fluoro-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogen and difluoromethoxy substitution pattern enables precise modulation of biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine motifs into complex molecules. The product is supplied under stringent quality control to ensure batch-to-batch consistency for critical synthetic applications.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials, leveraging its aromaticity and halogen content.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a substrate for further functionalization in academic and industrial research laboratories.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine and chlorine substitution on aromatic systems and reaction pathways.

Basic Information

Product Name	4-Chloro-2-(Difluoromethoxy)-1-Fluoro-Benzene
CAS No.	1404194-55-3
Molecular Formula	C7H4ClF3O
Molecular Weight	196.56 g/mol
Synonyms	1-Fluoro-4-chloro-2-(difluoromethoxy)benzene; 4-Chloro-1-fluoro-2-(difluoromethoxy)benzene; Benzene, 4-chloro-2-(difluoromethoxy)-1-fluoro-; 2-(Difluoromethoxy)-4-chloro-1-fluorobenzene; 4-Chloro-2-difluoromethoxy-1-fluorobenzene; 1-Fluoro-4-chloro-2-difluoromethoxybenzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Difluoromethoxy)-1-Fluoro-Benzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to strong alkali and highly volatile nature, keep away from heat, sparks, and open flame. Ensure containers are kept tightly sealed when not in use to prevent volatilization and potential contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.