Description

2-Chloro-4-(Difluoromethoxy)-1-Fluoro-Benzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring chloro, fluoro, and difluoromethoxy substituents, makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorine-containing motifs into complex molecules. The CAS number for this compound is 1404194-23-5.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly in areas like kinase inhibitors, anti-infectives, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides where the difluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), improving dielectric anisotropy and thermal stability.
• Organic Electronics: Employed in the development of novel materials for organic light-emitting diodes (OLEDs) and semiconductors due to its electron-withdrawing properties.
• Chemical Research: A versatile building block for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution in academic and industrial R&D settings.
• Fluorinated Polymer Modifiers: Can be incorporated into polymer backbones to alter physical properties such as chemical resistance, thermal stability, and surface energy.

Basic Information

Product Name	2-Chloro-4-(Difluoromethoxy)-1-Fluoro-Benzene
CAS No.	1404194-23-5
Molecular Formula	C7H4ClF3O
Molecular Weight	196.56 g/mol
Synonyms	1-Fluoro-2-chloro-4-(difluoromethoxy)benzene; 2-Chloro-1-fluoro-4-(difluoromethoxy)benzene; 4-(Difluoromethoxy)-2-chloro-1-fluorobenzene; 2-Chloro-α,α-difluoro-4-fluoroanisole; 1-Fluoro-2-chloro-4-(difluoromethoxy)benzene; Benzene, 2-chloro-1-fluoro-4-(difluoromethoxy)-; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Difluoromethoxy)-1-Fluoro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated pharmaceutical and agrochemical supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.