Description

1-Chloro-3-(Difluoromethoxy)-2-Fluoro-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its unique substitution pattern, which introduces both halogen and difluoromethoxy functionalities onto the benzene ring, enabling precise molecular modifications. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its specific structure is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a specialized monomer or building block for developing fluorinated polymers and liquid crystals with unique electronic and surface properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring novel fluorination chemistry and constructing complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the scale-up and production of client-specific target molecules.

Basic Information

Product Name	1-Chloro-3-(Difluoromethoxy)-2-Fluoro-Benzene
CAS No.	1404194-14-4
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	2-Fluoro-1-chloro-3-(difluoromethoxy)benzene; 3-(Difluoromethoxy)-2-fluorochlorobenzene; 1-Chloro-2-fluoro-3-(difluoromethoxy)benzene; Benzene, 1-chloro-3-(difluoromethoxy)-2-fluoro-; 2-Fluorophenyl chlorodifluoromethyl ether (related); FCB-Difluoromethoxy Intermediate
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-(Difluoromethoxy)-2-Fluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.