Description

4-Chloro-1-(difluoromethoxy)-2-fluoro-benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chloro and difluoromethoxy substituents, makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought by R&D and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Liquid Crystal Materials: Serves as a fluorinated core component in the synthesis of advanced liquid crystals for display technologies.
• Organic Electronic Materials: Employed as a building block for electron-transport materials, semiconductors, and other functional materials in OLEDs and OFETs.
• Chemical Research & Development: A versatile reagent for exploring novel fluorination chemistry and creating specialized chemical libraries for screening.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical producers for use in custom synthesis projects under cGMP or ISO quality systems.

Basic Information

Product Name	4-Chloro-1-(difluoromethoxy)-2-fluoro-benzene
CAS No.	1404194-13-3
Molecular Formula	C7H4ClF3O
Molecular Weight	196.56 g/mol
Synonyms	1-Chloro-4-(difluoromethoxy)-3-fluorobenzene; 3-Fluoro-4-chlorophenyl difluoromethyl ether; 4-Chloro-3-fluoroanisole, 2,2-difluoro; 2-Fluoro-4-chloro-1-(difluoromethoxy)benzene; Benzene, 4-chloro-1-(difluoromethoxy)-2-fluoro-; CAS 1404194-13-3
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-(difluoromethoxy)-2-fluoro-benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment. Our quality commitment supports applications requiring high-purity intermediates under ISO, cGMP, or other regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.