Description

2-(Difluoromethoxy)-1,4-Difluoro-Benzene is a specialized fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique difluoromethoxy and difluoro substitution pattern makes it a valuable intermediate for creating molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients, where fluorine incorporation is a key strategy to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a fluorine-containing precursor in the synthesis of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Material Science: Employed as a monomer or modifier to introduce fluorine into polymers, improving chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitutions to construct complex, fluorinated molecular architectures for various R&D purposes.

Basic Information

Product Name	2-(Difluoromethoxy)-1,4-Difluoro-Benzene
CAS No.	1404193-91-4
Molecular Formula	C7H4F4O
Molecular Weight	180.10 g/mol
Synonyms	1,4-Difluoro-2-(difluoromethoxy)benzene; Benzene, 1,4-difluoro-2-(difluoromethoxy)-; 2-(Difluoromethoxy)-1,4-difluorobenzene; 1,4-Difluoro-2-(difluoromethoxy)benzene; DFDFB (abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)-1,4-Difluoro-Benzene is produced and analyzed under a strict quality management system. We guarantee high-purity material suitable for demanding R&D and scale-up applications. Comprehensive testing includes identity confirmation, assay (purity), and detailed impurity profiling by GC/HPLC. A Certificate of Analysis (COA) documenting all critical parameters is provided with each shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.