Description

2-Chloro-1-(Difluoromethoxy)-3-Fluoro-Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine and chlorine atoms is crucial for modulating biological activity and stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate unique difluoromethoxy and halogenated motifs into novel molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, multi-substituted benzene derivatives.
• Fluorine Chemistry Research: An important substrate for studying the reactivity and applications of difluoromethoxy ethers in academic and industrial R&D settings.

Basic Information

Product Name	2-Chloro-1-(Difluoromethoxy)-3-Fluoro-Benzene
CAS No.	1404193-54-9
Molecular Formula	C7H4ClF3O
Molecular Weight	196.56 g/mol
Synonyms	1-Chloro-2-(difluoromethoxy)-4-fluorobenzene; 2-Chloro-α,α-difluoro-3-fluoroanisole; 3-Fluoro-2-chloro-1-(difluoromethoxy)benzene; Benzene, 2-chloro-1-(difluoromethoxy)-3-fluoro-; 4-Fluoro-2-chloro-1-(difluoromethoxy)benzene; 2-Chloro-3-fluoro-α,α-difluoroanisole; 1-(Difluoromethoxy)-2-chloro-3-fluorobenzene
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-(Difluoromethoxy)-3-Fluoro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.