Description

Ald-Ph-PEG3-Amine is a heterobifunctional polyethylene glycol (PEG) linker featuring an aldehyde group and a primary amine, separated by a triethylene glycol spacer. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the site-specific coupling of biomolecules, drugs, and surfaces. It is primarily utilized by researchers and manufacturers in the fields of biotechnology, pharmaceuticals, and diagnostics for creating stable, functionalized conjugates.

Application

• Bioconjugation Reagent: For the site-specific crosslinking of proteins, peptides, antibodies, and oligonucleotides via amine-aldehyde chemistry.
• ADC (Antibody-Drug Conjugate) Development: As a key linker component to attach cytotoxic payloads to monoclonal antibodies, enhancing therapeutic targeting.
• Surface Functionalization: For modifying nanoparticles, biosensors, and solid supports to introduce reactive amine or aldehyde groups for further coupling.
• PEGylation: To introduce a hydrophilic PEG spacer between molecules, improving solubility, stability, and pharmacokinetic profiles of therapeutic agents.
• Polymer Chemistry: As a monomer or chain extender in the synthesis of functionalized polymers and hydrogels for biomedical applications.
• Diagnostic Assay Development: In the preparation of enzyme-linked or fluorescently labeled probes and reagents for immunoassays.

Basic Information

Product Name	Ald-Ph-PEG3-Amine
CAS No.	1404111-56-3
Molecular Formula	C17H25NO5
Molecular Weight	323.39 g/mol
Synonyms	4-Formylbenzyl-PEG3-amine; 4-(3-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}benzyl)benzaldehyde; Aldehyde-PEG3-Amine Benzyl; Fmoc-PEG3-CH2-CH2-aldehyde; (Aldehyde-PEG3)-amine; Benzaldehyde-PEG3-NH2; Amino-PEG3-benzaldehyde; 1-Amino-3,6,9-trioxa-12-azatetradecan-14-al
EINECS	Contact for details

Quality Control

Our Ald-Ph-PEG3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its sensitivity to moisture and oxidation. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.