Description

n-[(9R)-6'-Methoxycinchonan-9-Yl]-4-(Trifluoromethyl)-1,2-Benzenediamine is a high-purity, advanced pharmaceutical intermediate characterized by its complex chiral structure. This compound is critical for the synthesis of specialized active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics and chiral catalysts. The CAS number for this compound is 1404088-26-1.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, chiral active pharmaceutical ingredients (APIs).
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for stereoselective synthesis.
• Medicinal Chemistry Research: Used in drug discovery programs for lead optimization and structure-activity relationship (SAR) studies.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the design of molecular probes to study biological systems and enzyme mechanisms.

Basic Information

Product Name	n-[(9R)-6'-Methoxycinchonan-9-Yl]-4-(Trifluoromethyl)-1,2-Benzenediamine
CAS No.	1404088-26-1
Molecular Formula	C27H26F3N3O
Molecular Weight	465.51 g/mol
Synonyms	(9R)-N-[4-(Trifluoromethyl)-1,2-benzenediamino]-6'-methoxycinchonan; 4-(Trifluoromethyl)-1,2-benzenediamine N-[(9R)-6'-Methoxycinchonan-9-yl]-; Cinchonan-9-amine, N-[4-(trifluoromethyl)-1,2-phenylenediamine]-6'-methoxy-, (9R)-; (R)-N-(4-(Trifluoromethyl)benzene-1,2-diamino)-6'-methoxycinchonan
EINECS	Contact for details

Quality Control

Our n-[(9R)-6'-Methoxycinchonan-9-Yl]-4-(Trifluoromethyl)-1,2-Benzenediamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.