Description

Fmoc-Cys(Stmp)-Oh is a specialized, orthogonally protected cysteine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling the precise and efficient construction of complex peptides and proteins, particularly those requiring specific disulfide bond formation or post-translational modifications. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who are developing peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, facilitating the sequential assembly of peptide chains.
• Peptide Drug Discovery & Development: Used in the research and production of therapeutic peptides, including hormones, antimicrobial peptides, and targeted drug conjugates.
• Disulfide Bridge Engineering: The Stmp (S-tert-butylmercapto) protecting group allows for controlled formation of intramolecular and intermolecular disulfide bonds, crucial for protein folding and stability.
• Bioconjugation & Labeling: Serves as a handle for site-specific modification of peptides and proteins with fluorophores, tags, or other functional molecules.
• Chemical Biology Research: Employed in studying protein-protein interactions, enzyme mechanisms, and developing biochemical assays.
• Production of Custom Peptides: Essential for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Cys(Stmp)-Oh
CAS No.	1403834-74-1
Molecular Formula	C₂₃H₂₇NO₅S₂
Molecular Weight	461.59 g/mol
Synonyms	Fmoc-Cys(StBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(tert-butylthio)-L-cysteine; Fmoc-S-tert-butylmercapto-L-cysteine; Fmoc-Cys(StBu)-OH; Fmoc-Cysteine(S-tert-butylmercapto); (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[(tert-butylsulfanyl)thio]propanoic acid; Fmoc-L-Cys(StBu)-OH; Fmoc-Cys(S-tBu)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Stmp)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation via NMR and mass spectrometry. We provide Certificates of Analysis (COA) with every shipment, detailing all specifications to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a cool, dry place. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.