Description

(2S)-3-Chloro-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid is a specialized, optically pure amino acid derivative designed for advanced synthetic chemistry. This compound is a critical building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the production of high-value active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid building block for the controlled assembly of peptide chains.
• Pharmaceutical Intermediate: Synthesis of novel therapeutic peptides and peptidomimetic drug candidates targeting various diseases.
• Bioconjugation: Used to introduce specific functional handles or chloroalkyl groups into biomolecules for labeling or linker attachment.
• Chemical Biology Research: Tool compound for studying protein-protein interactions and enzyme mechanisms.
• Process Chemistry: Intermediate in the scalable production of chiral compounds under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Potential intermediate for the development of bioactive compounds with specific chiral requirements.

Basic Information

Product Name	(2S)-3-Chloro-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid
CAS No.	1403834-71-8
Molecular Formula	C18H16ClNO4
Molecular Weight	345.78 g/mol
Synonyms	Fmoc-3-chloro-L-alanine; Fmoc-L-3-chloroalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-chloro-L-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-chloropropanoic acid; Fmoc-Chloroalanine-OH; Fmoc-3-Cl-Ala-OH; Nα-Fmoc-3-chloro-L-alanine; L-3-Chloroalanine N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our (2S)-3-Chloro-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Propanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material with specifications tailored to client requirements, including potential GMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.