Description

2-Fmoc-6-Oxo-1,3,4,4A,5,7,8,8A-Octahydroisoquinoline-3-Carboxylic Acid is a sophisticated, high-purity building block designed for advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise molecular architecture in complex chemical processes. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• API Development: Serves as a crucial building block in the research and production of novel drug candidates, particularly in oncology and neurology.
• Combinatorial Chemistry: Used in the generation of diverse chemical libraries for high-throughput screening and drug discovery programs.
• Bioconjugation: Employed in the synthesis of peptide-drug conjugates (PDCs) and other targeted therapeutic agents.
• Academic & Contract Research: Essential for synthetic chemistry research in universities and contract research organizations (CROs) focusing on heterocyclic and peptide chemistry.

Basic Information

Product Name	2-Fmoc-6-Oxo-1,3,4,4A,5,7,8,8A-Octahydroisoquinoline-3-Carboxylic Acid
CAS No.	1403766-52-8
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-Octahydroisoquinoline-3-carboxylic Acid; 2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-6-oxo-1,3,4,4a,5,7,8,8a-octahydroisoquinoline-3-carboxylic Acid; 2-Fmoc-6-oxodecahydroisoquinoline-3-carboxylic Acid; Fmoc-DHIQ-3-COOH; (3S,4aR,8aR)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-6-oxooctahydroisoquinoline-3-carboxylic Acid; (3S,4aR,8aR)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-6-oxo-1,3,4,4a,5,7,8,8a-octahydroisoquinoline-3-carboxylic Acid; Fmoc-protected Octahydroisoquinolinecarboxylic Acid; CAS 1403766-52-8
EINECS	Contact for details

Quality Control

Our production of 2-Fmoc-6-Oxo-1,3,4,4A,5,7,8,8A-Octahydroisoquinoline-3-Carboxylic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.