Description

Fmoc-L-Penicillamine CAS NO 1403693-21-9 is a protected derivative of the non-proteinogenic amino acid L-penicillamine, featuring the fluorenylmethyloxycarbonyl (Fmoc) protecting group on the amine functionality. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptide chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity, specialized amino acids for the development of novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of custom peptides and peptidomimetics.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based drugs, including potential treatments for autoimmune disorders, cancer, and infectious diseases.
• Bioconjugation & Chemical Biology: Serves as a key intermediate for creating peptide-protein conjugates, labeled probes, and other biomolecular constructs.
• Material Science: Employed in the synthesis of peptide-derived polymers, hydrogels, and surface coatings with specific biological or chemical properties.
• Academic & Contract Research: A vital reagent for universities and CROs conducting fundamental research in medicinal chemistry, biochemistry, and molecular biology.

Basic Information

Product Name	Fmoc-L-Penicillamine
CAS No.	1403693-21-9
Molecular Formula	C₂₀H₂₁NO₄S
Molecular Weight	371.45 g/mol
Synonyms	Fmoc-Pen-OH; Fmoc-L-β,β-Dimethylcysteine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-penicillamine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,3-dimethylbutanethioic acid; N-Fmoc-L-penicillamine; Fmoc-Cys(Me)₂-OH; Fmoc-Dmp-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-Penicillamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for advanced research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.