Description

Fmoc-α-Me-Asn-Oh is a protected, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing structural modifications and enhancing the metabolic stability of synthetic peptides. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Peptidomimetic Drug Development: Used to incorporate α-methyl-asparagine analogs into peptide backbones to improve stability against enzymatic degradation.
• Medicinal Chemistry Research: Serves as a crucial intermediate in structure-activity relationship (SAR) studies for new drug candidates.
• Bioconjugation: Acts as a specialized linker or modified residue in the synthesis of peptide-based conjugates for targeted drug delivery.
• High-Purity Reference Standard: Utilized as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of modified peptides for high-throughput screening.

Basic Information

Product Name	Fmoc-α-Me-Asn-Oh
CAS No.	1403590-49-7
Molecular Formula	C₂₀H₂₀N₂O₅
Molecular Weight	368.39 g/mol
Synonyms	Fmoc-α-methyl-L-asparagine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-L-asparagine; Fmoc-α-Me-Asn-OH; Fmoc-α-Me-L-Asn-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methyl-3-carbamoylpropanoic acid; N-α-Fmoc-α-methylasparagine; Fmoc-α-methyl-asparagine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-α-Me-Asn-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality standards are designed to meet the rigorous demands of GMP and cGMP environments for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.